inflammatory skin diseases — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T4558	Trioxsalen	Trimethylpsoralen,Trioxysalen,Trisoralen	DNA Alkylator/Crosslinker , DHFR
	Trioxsalen (Trioxysalen) is a furanocoumarin and a psoralen derivative, in conjunction with UV-A for phototherapy treatment of vitiligo and hand eczema. After photoactivation it creates interstrand cross-links in DNA, wh...		DNA Alkylator/Crosslinker , DHFR
T2648	Pimecrolimus	SDZ-ASM 981,ASM 981	Others
	Pimecrolimus (SDZ-ASM 981), a calcineurin inhibitor immunosuppressant, binds to the receptor macrophilin-12 (FKBP-12) forming a complex that blocks the calcium-dependent signal transduction cascade mediated by calcineuri...		Others
T4966	Ufenamate	Flufenamic acid butyl ester,Butyl flufenamate	Others
	Ufenamate (Flufenamic acid butyl ester) is an anthranilic acid-based anti-inflammatory drug developed for skin diseases		Others
TN6464	Hemiphloin		Others
	Hemiphloin is a natural flavonoid compound. Studies have shown it to have anti-inflammatory activity and is a therapeutic candidate for inflammatory skin diseases.		Others
T5S0993	Kurarinone		BCL , Others , IκB/IKK , TNF , NF-κB , JAK , STAT
	Kurarinone, a flavanoid derived from shrub Sophora flavescens,Kurarinone exhibits anti-tumor, estrogenic, and anti-inflammatory activities, it also shows strong inhibitory effect on immune responses. Kurarinone may ameli...		BCL , Others , IκB/IKK , TNF , NF-κB , JAK , STAT
TQ0131	Rocaglamide	Rocaglamide A,Roc-A	HSP , NF-κB , PERK
	Rocaglamide (Roc-A), isolated from the genus Aglaia, can be used to treat coughs, injuries, asthma, and inflammatory skin diseases. It is a potent inhibitor of NF-κB activation in T-cells.		HSP , NF-κB , PERK
T4S2126	Ginkgetin		Apoptosis , Wnt/beta-catenin , COX , STAT , Autophagy
	1. Ginkgetin has anti-influenza virus and anti-fungal activities. 2. Ginkgetin has anti-inflammatory activity, can down-regulates COX-2 induction in vivo against skin inflammatory responses. 3. Ginkgetin is a good STAT3 ...		Apoptosis , Wnt/beta-catenin , COX , STAT , Autophagy
T77677	12R-LOX-IN-2		Lipoxygenase
	12R-LOX-IN-2 is an inhibitor of 12R-lipoxygenase (12R-LOX).12R-LOX-IN-2 inhibits imiquimod (IMQ)-induced hyperproliferation of psoriatic keratinocytes and inhibits colony formation.12R-LOX-IN-2 also decreases the protein...		Lipoxygenase
T32113	Hydrocortamate Hydrochloride	UNII-9QM8U7R83W,Ulcort,Hydrocortamate HCl,Magnacort,Ethamicort
	Hydrocortamate Hydrochloride is a synthetic glucocorticoid that has anti-inflammatory and immunosuppressive properties. It is used topically to treat inflammation caused by corticosteroid-responsive skin diseases.
T13578	Betamethasone-17-butyrate-21-propionate		Others
	Betamethasone-17-butyrate-21-propionate is a topical corticosteroid and may be used in the treatment of inflammatory skin diseases.		Others
T78207	Lepzacitinib		JAK
	Lepzacitinib, a Janus kinase inhibitor, specifically targets JAK 1/3. It demonstrates an anti-inflammatory effect and efficacy in inhibiting atopic dermatitis as well as other skin diseases [1].		JAK
T60238	Acloproxalap
	Acloproxalap is a quinoline-based aldehyde scavenger that can be used in studies of diseases with toxic aldehyde accumulation, such as inflammatory diseases of the eye and skin, respiratory diseases such as pneumonia, or...
T71089	PF-00956980
	PF-00956980 is a reversible pan-JAK inhibitor, exhibiting IC50 values of 2.2 μM for JAK1, 23.1 μM for JAK2, and 59.9 μM for JAK3. It is utilized in the study of lung and skin inflammatory diseases.
T77032	Imsidolimab
	Imsidolimab (ANB 019), a high-affinity, humanized monoclonal antibody targeting IL-36R, antagonizes IL-36 cytokine signal transduction, showing potential in treating generalized pustular psoriasis (GPP) and other inflamm...
T60981	TRPC4/5-IN-1
	TRPC4/5-IN-1 can be used for the research of skin inflammatory diseases and proteinuric kidney diseases. TRPC4/5-IN-1 is a potent inhibitor of TRP channel 5/4 (TRPC5/4) with IC50 values of 0.54 μM and 2.06 μM, respective...
TN4213	Hirsutenone		ERK , EGFR , IL Receptor , NF-κB , Akt , PI3K , Antifection , mTOR , p53 , Autophagy
	Hirsutenone has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid peroxidation.Hirsutenone exhibits anti-cancer, and anti-filaria...
T78208	Leramistat	HMC-C-01-A,MBS2320	Mitochondrial Metabolism
	Leramistat (HMC-C-01-A; MBS2320), a mitochondrial complex 1 inhibitor, plays a role in regulating cell and immune metabolism. It is effective in suppressing various conditions, including atopic dermatitis, autoimmune ski...		Mitochondrial Metabolism